Disney’s Alice in Wonderland (1951)

Said all art historians, ever.

Disney’s Alice in Wonderland (1951)

Said all art historians, ever.

(Reblogged from vintagegal)

Anonymous asked: Should I rewatch Star Wars in order of release or in story order?

soloontherocks:

I AM HERE FOR THIS QUESTION.

I’m about to blow your mind.

NEITHER.

Read More

And now you know.

(Reblogged from soloontherocks)

androphilia:

Shabaka by Rashad Alakbarov, 2011

(Reblogged from androphilia)

gacougnol:

Paul Rand
Direction Magazine n° 2
March 1939

(Reblogged from gacougnol)

neurosciencestuff:

How a small worm may help the fight against Alzheimer’s

Scientists at the Max Planck Institute for Biology of Ageing in Cologne have found that a naturally occurring molecule has the ability to enhance defense mechanisms against neurodegenerative diseases. Feeding this particular metabolite to the small round worm Caenorhabditis elegans, helps clear toxic protein aggregates in the body and extends life span.

During ageing, proteins in the human body tend to aggregate. At a certain point, protein aggregation becomes toxic, overloads the cell, and thus prevents it from maintaining normal function. Damage can occur, particularly in neurons, and may result in neurodegenerative diseases like Alzheimer’s, Parkinson’s or Huntington’s disease. By studying model organisms like Caenorhabditis elegans, scientists have begun to uncover the mechanisms underlying neurodegeneration, and thus define possible targets for both therapy and prevention of those diseases. “Although we cannot measure dementia in worms“, explains Martin Denzel of the Max Planck Institute for Biology of Ageing, “we can observe proteins that we also know from human diseases like Alzheimer’s to be toxic by measuring effects on neuromuscular function. This gives us insight into how Alzheimer actually progresses on the molecular level“.

Now, the scientists Martin Denzel, Nadia Storm, and Max Planck Director Adam Antebi have discovered that a substance called N-acetylglucosamine apparently stimulates the body’s own defense mechanism against such toxicity. This metabolite occurs naturally in the organism. If it is additionally fed to the worm, “we can achieve very dramatic benefits“, says Denzel. “It is a broad-spectrum effect that alleviates protein toxicity in Alzheimer’s, Parkinson’s and Huntington’s disease models in the worm, and it even extends their life span.“

This molecule apparently plays a crucial role in quality control mechanisms that keep the body healthy. It helps the organism to clear toxic levels of protein aggregation, both preventing aggregates from forming and clearing already existing ones. As a result, onset of paralysis is delayed in models of neurodegeneration - How exactly the molecule achieves this effect is yet to be uncovered. “And we still don’t know whether it also works in higher animals and humans“, says Antebi. “But as we also have these metabolites in our cells, this gives good reason to suspect that similar mechanisms might work in humans.”

(Reblogged from androphilia)

gregmelander:

BELOW THE SURFACE

Amazing illustrations of what might be below the surface.  At the Schusev State Museum of Architecture via iheartmyart

(Source: taktophoto)

(Reblogged from nobodysuspectsthebutterfly)

camwyn:

animatedamerican:

winneganfake:

doctorwho:

browsethestacks:

ed-pool:

What if Doctor Who was an American show?

(via BuzzFeed)

<OMG>

¡¡¡Best Post Ever!!!

'What if Doctor Who was an American Show' fan casting.

….my brain’s bleeding now, I think.

I am torn between OW OW OW and YES GOOD PERFECT, leaning slightly more to the latter.

For the prospect of Vincent Price as the Doctor, I’m gonna put this firmly in the yes-good-perfect column.

NIC CAGE AS CHRISTOPHER ECCLESTON/NINTH DOCTOR

(Reblogged from nobodysuspectsthebutterfly)

lowgarden:

Jaime Lannister’s Inbox

This brings me so much joy.

(Reblogged from nobodysuspectsthebutterfly)
steampunktendencies:

The Rookery. Burnham and Root. Completed in 1888. Frank Lloyd Wright redesigned the skylit lobby in 1905. Chicago, Illinois.
Photo by Stuart Grais
…
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Steampunk Tendencies Official Group

steampunktendencies:

The Rookery. Burnham and Root. Completed in 1888. Frank Lloyd Wright redesigned the skylit lobby in 1905. Chicago, Illinois.

Photo by Stuart Grais

FacebookGoogle + | Twitter

Steampunk Tendencies Official Group

(Reblogged from nobodysuspectsthebutterfly)

gacougnol:

Pavel Brunclik

From “The Geometry of Nudity” (dancers of the National Theatre ballet in Prague)
2006-2007

(Reblogged from gacougnol)